Celosome Mid with Lidocaine (1 x 1.1 mL) | ExoCoBio
Short Description
A balanced, versatile Hyaluronic Acid dermal filler formulated with 24 mg/mL of cross-linked HA, 0.3% lidocaine, and patented HENM (High concentration Equalized cross-linked Network Membrane) technology. Calibrated for mid-to-deep dermal placement and lip mucosal tissue, Celosome Mid delivers smooth volumetric correction, exceptional tissue integration, and natural dynamic flexibility for moderate-to-severe facial folds, lip contouring, and perioral rejuvenation lasting 9 to 12 months.
Detailed Description
Celosome Mid is a sterile, non-pyrogenic physiological cross-linked sodium hyaluronate injectable developed by ExoCoBio (South Korea). Engineered as the versatile core workhorse of the Celosome line, it balances lifting power ($G’$) and cohesive spreadability to treat tissue depressions without creating palpable firmness or visible borders.
Manufactured using proprietary HENM technology, Celosome Mid interlocks hyaluronic acid chains into a uniform, equalized 3D membrane network. Subjected to an exhaustive 8-stage membrane dialysis process, unreacted BDDE monomers and heavy chemical residues are reduced to undetectable levels, dramatically diminishing the likelihood of post-injection erythema, swelling, or delayed immune hypersensitivity. The resulting hydrogel flows smoothly into the mid-to-deep reticular dermis, moving synchronously with dynamic facial expressions while maintaining structural integrity against everyday muscle movement.
Treatment Areas & Indications
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Moderate-to-Severe Facial Folds & Depressions:
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Moderate-to-deep nasolabial folds (smile lines running from the nasal ala to mouth angles)
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Marionette lines and oral commissure softening
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Glabellar lines and deep forehead furrows (when dermal filling is indicated)
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Lip Augmentation & Perioral Enhancement:
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Full lip volume enhancement and mucosal plumping
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Vermilion border sharpening and Cupid’s bow definition
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Philtral column contouring and perioral line smoothing
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Midface & Cheek Softening:
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Moderate cheek creases and accordion smile lines
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Labiomental groove (mental crease between lower lip and chin) softening
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Atrophic facial scar elevation
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Key Clinical Advantages
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Patented HENM Balanced Viscoelasticity: Provides optimal shear resistance and cohesive fluidity, delivering smooth tissue filling that adapts naturally to high-mobility zones like the lips and perioral area.
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Ultra-Low BDDE & High Biocompatibility: Purified via an 8-stage dialysis filtration protocol that strips away residual cross-linkers, ensuring minimal post-treatment swelling, zero Tyndall effect, and patient tolerance.
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10% Extra Volume (1.1 mL Syringe): Packed with 1.1 mL of hydrogel per syringe, offering clinicians a 10% volume advantage over standard 1.0 mL industry alternatives for more comprehensive full-treatment coverage.
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Integrated 0.3% Lidocaine: Formulated with lidocaine hydrochloride to numb the treatment plane during extrusion, ensuring patient comfort during sensitive perioral and lip procedures.
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Natural Dynamic Expression: Integrates directly between host dermal collagen fibers, preventing gel migration, nodule formation, or an unnatural, stiff appearance during speaking and smiling.
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Dependable Longevity: Highly resistant to free-radical shear and endogenous hyaluronidase, sustaining corrective results for 9 to 12 months.
Technical Specifications
| Parameter | Specification |
| Active Substance | Cross-linked Sodium Hyaluronate + 0.3% Lidocaine Hydrochloride |
| HA Concentration | 24 mg/mL |
| Lidocaine Concentration | 3 mg/mL (0.3% w/v) |
| Cross-Linking Technology | HENM (High concentration Equalized cross-linked Network Membrane) |
| Syringe Volume | 1 x 1.1 mL pre-filled sterile glass syringe |
| Included Needles | 2 x 27G 1/2” (13 mm) or 30G 1/2” ultra-thin wall disposable needles |
| Target Injection Plane | Mid-to-deep dermis and lip mucosal submucosa |
| Recommended Injection Tools | 27G / 30G needle or 25G / 27G blunt-tip microcannula |
| Expected Clinical Duration | 9 to 12 months (dependent on treated area, technique, and patient metabolism) |
| Storage Instructions | Store between 2°C to 25°C (36°F to 77°F); protect from direct sunlight and freezing |
| Manufacturer | ExoCoBio Co., Ltd. (South Korea) |
| Regulatory Category | Medical Device / CE-marked / Prescription Only (Rx) |
Professional Advisory: Celosome Mid with Lidocaine is a medical-grade injectable device intended strictly for certified dermatologists, plastic surgeons, and credentialed aesthetic physicians skilled in mid-dermal and advanced lip injection techniques. Not authorized for superficial injection or non-clinical consumer use.






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