HYARON® Prefilled Inj. (10 x 2.5 mL) | DongKook Pharmaceutical (South Korea)

Short Description

A high-yield, medical-grade biorevitalizing skin booster formulated with 25 mg / 2.5 mL (10 mg/mL) of non-cross-linked Sodium Hyaluronate. Manufactured by South Korea’s DongKook Pharmaceutical in a clinical box of 10 pre-filled syringes (25 mL total volume), HYARON® delivers intensive multi-layer hydration, restores dermal turgor, accelerates cellular repair, and smooths superficial dehydration rhytids—serving as one of the most cost-effective and versatile workhorses for full-face mesotherapy, meso-gun protocols, and post-procedure barrier recovery.

Detailed Description

HYARON® Prefilled Inj. is a sterile, non-pyrogenic, transparent viscoelastic gel manufactured in South Korea by DongKook Pharmaceutical Co., Ltd. Widely regarded across international aesthetic medicine as the quintessential foundational skin booster, Hyaron provides pure, unadulterated physiological hydration to dry, photo-damaged, and environmentally stressed cutaneous tissue.

The formulation is synthesized from medical-grade, non-animal bio-fermented sodium hyaluronate. Unlike cross-linked volumizing fillers, Hyaron contains linear, non-cross-linked hyaluronic acid (10 mg/mL) optimized for high biological bioavailability and smooth tissue dispersion:

1. Immediate Hydraulic Osmoregulation: Upon delivery into the papillary and upper reticular dermis, the linear HA chains bind up to 1,000 times their molecular weight in water, rapidly restoring interstitial fluid balance and arresting transepidermal water loss (TEWL).

2. CD44 Receptor Activation: The high-purity linear HA fragments interact with cell-surface CD44 receptors on resident dermal fibroblasts. This biochemical trigger stimulates the endogenous synthesis of native hyaluronic acid and extracellular matrix (ECM) structural components.

3. Optimized Viscoelastic Fluidity: Formulated with calibrated viscosity and low extrusion resistance, it spreads evenly across the horizontal dermal plane without forming persistent lumps or causing hydrophilic tissue distortion.

4. 100% BDDE-Free Purity: Free of synthetic chemical cross-linking agents, the hydrogel integrates smoothly and metabolizes cleanly through physiological hyaluronidase pathways with negligible risk of late-onset immune granulomas.

Treatment Areas & Indications

• Full-Face Hydro-Revitalization & Dehydration:

  • Chronically parched, dull, and sallow skin lacking natural glow and bounce

  • Superficial dehydration crinkles, forehead fine lines, and perioral micro-rhytids

  • Loss of skin elasticity, turgor, and epidermal suppleness

• Periorbital & Delicate Expression Zones:

  • Superficial fine wrinkles around the lateral orbital rim (crow’s feet)

  • Under-eye dehydration creasing (administered in the superficial papillary dermis without bolus pooling)

• Cervical & Décolletage Rejuvenation:

  • Horizontal neck rings (“necklace bands”) and sun-damaged chest crepeyness

• Dorsal Hand & Body Conditioning:

  • Restoring moisture to thin, weathered hands

  • Addressing crepey skin texture on the elbows, knees, and inner upper arms

• Post-Procedure Recovery & Barrier Optimization:

  • Accelerating epidermal re-epithelialization and calming erythema following chemical peels, ablative/non-ablative fractional lasers, and microneedling RF

Key Clinical Advantages

• High-Capacity 10-Syringe Clinic Packaging: Each box provides 10 pre-filled syringes of 2.5 mL (25 mL total), giving clinics high volume efficiency and low cost-per-treatment.

• Generous 2.5 mL Volume per Syringe: Exceeds the standard 1.0 mL booster format, allowing complete, unconstrained coverage of the full face (or face + upper neck) using a single syringe.

• Ready-to-Inject Prefilled Format: Eliminates the need to draw solution from rubber-stopper vials, reducing preparation time and maintaining strict closed-system sterility.

• Rapid Papule Absorption: Because the HA is non-cross-linked and highly physiological, intradermal micro-papules typically flatten and absorb within 12 to 36 hours.

• High Multi-Modality Utility: Functions smoothly via manual micro-papular mesotherapy, automated multi-needle meso-injectors (Meso-guns), or transdermal microneedling (MTS).

• High Biocompatibility Profile: Produced under strict pharmaceutical GMP standards, minimizing residual endotoxins and proteins to eliminate allergic responses.

Technical Specifications

Parameter	Specification
Product Classification	Injectable Biorevitalizing Skin Booster / Physiological Dermal Hydrogel
Manufacturer / Origin	DongKook Pharmaceutical Co., Ltd.
(South Korea)
Active Substance	Sodium Hyaluronate (Non-animal bio-fermentation)
HA Concentration	10.0 mg/mL (1.0% solution)
Total HA Load per Syringe	25.0 mg per 2.5 mL pre-filled syringe
HA Cross-Linking Status	Linear, Non-Cross-Linked (100% BDDE-Free)
Packaging Presentation	Clinic box of 10 x 2.5 mL pre-filled sterile glass syringes (25 mL total)
Lidocaine Content	Lidocaine-free (compatible with pre-treatment topical anesthetic cream)
Target Injection Planes	Superficial dermis, papillary dermis, or epidermal-dermal junction (0.5 mm to 1.5 mm depth)
Recommended Injection Tools	30G / 32G / 34G (4 mm) meso needles, 9-pin automated injector cartridges, or microneedling pens
Application Techniques	Intradermal micro-papules (0.02–0.05 mL per point, 0.5–1 cm grid), nappage, or automated meso-gun
Standard Treatment Protocol	Induction: 4 to 5 sessions spaced 10 to 14 days apart; Maintenance: 1 session every 4 to 8 weeks
Papule Resolution Time	Typically flattens and absorbs within 12 to 36 hours post-treatment
Expected Clinical Longevity	6 to 9 months cumulative cellular improvement following an induction series
Storage Instructions	Store between 1°C and 30°C (34°F to 86°F) in a hermetic container; protect from light and freezing
Regulatory Category	Korean MFDS (KFDA) Approved / CE-certified Medical Device / Prescription Only (Rx)

Clinical Delivery Protocols & Technique Options

Modality	Instrument Setup	Technique & Dosing	Clinical Endpoint
Manual Micro-Papular (Classic Meso)	32G or 34G x 4 mm micro-meso needle on 2.5 mL syringe	30-degree needle angle; deliver 0.02–0.05 mL per micro-bleb spaced 5–10 mm across the face	Precision hydration along fine lines, periorbital zone, and perioral area
Automated Meso-Injector (Meso-Gun)	5-pin or 9-pin multi-needle vacuum cartridge (31G/32G)	Calibrate suction depth to 0.8–1.2 mm; dose 0.02 mL per trigger pull across whole face	Rapid, uniform full-face coverage with minimal pain and consistent depth control
Transdermal Microneedling (MTS)	Automated microneedling pen (12/24/36-pin cartridge)	Set needle depth to 0.5–1.0 mm; glide syringe contents evenly over micro-channels	Surface hydration, epidermal glow, and skin barrier restoration
Cocktail Mixing (Clinic Synergy)	Blended with PDRN (e.g., Curenex / Gevinex), Glutathione, or Vitamin C	Mix 1.5 mL Hyaron with 1.0 mL active solution via female-to-female connector	Dual hydration and brightening/regenerative signaling in a single session

Comparative Benchmark: Foundational Hydration Boosters

Feature	HYARON® (DongKook)	CURENEX® (Synoia)	CYTOCARE® 532 (Revitacare)	RESTYLANE® Vital (Galderma)
Primary Base	Pure Linear HA (10 mg/mL)	PDRN + Multi-Peptides + HA	Linear HA (32 mg) + Multivitamins	Cross-Linked HA (20 mg/mL NASHA)
Packaging / Yield	10 x 2.5 mL Syringes (25 mL)	5 x 5 mL Vials (25 mL)	10 x 5 mL Vials (50 mL)	1 x 1.0 mL Syringe (1 mL)
Ready-to-Inject Syringe?	Yes (Pre-filled glass syringe)	No (Vials require syringe draw)	No (Vials require syringe draw)	Yes (Smart Click syringe)
Cross-Linking Status	Non-cross-linked (BDDE-free)	Non-cross-linked	Non-cross-linked	Lightly cross-linked (NASHA)
Primary Indication	Core hydro-plumping & turgor	Tissue regeneration & whitening	Intensive cellular bio-revitalization	Structural hydro-reserve & deep lines
Cost-to-Volume Ratio	Ultra-Economical	Moderate-to-Economical	Moderate	Premium

Professional Advisory: HYARON® is a professional-grade medical aesthetic injectable intended strictly for certified dermatologists, plastic surgeons, and credentialed aesthetic physicians. Because it is non-cross-linked, it must not be utilized as a deep structural or contouring filler. Intravascular or deep subcutaneous bolus injection is strictly contraindicated.