Belotero® Balance (1 x 1.0 mL) | Merz Aesthetics
Short Description
The versatile flagship in the CPM® range, Belotero® Balance (22.5 mg/mL HA) is engineered for the seamless correction of moderate-to-severe facial lines, perioral rhytids, and delicate under-eye hollows (tear troughs). Featuring Merz’s patented CPM® (Cohesive Polydensified Matrix) technology, it provides dynamic tissue integration that adapts to facial movements without lump formation or the risk of the bluish Tyndall effect.
Detailed Description
Belotero® Balance is a sterile, non-pyrogenic, cross-linked hyaluronic acid dermal filler designed to treat moderate cutaneous depressions and restore subtle dermal contours. Formulated using Merz’s proprietary CPM® Dynamic Cross-Linking technology, it consists of variable-density micro-zones within a cohesive, monophasic gel network.
This distinct rheological profile bridges the gap between deep lifting agents and ultra-fluid skin boosters. Belotero Balance integrates directly into the reticular and mid-dermal ECM (extracellular matrix), spreading evenly into tissue clefts. It respects natural dynamic facial expressions and allows injectors to treat delicate, thin-skinned areas—such as the infraorbital tear trough and perioral rim—with complete anatomical confidence.
Treatment Areas & Indications
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Periorbital & Tear Trough Rejuvenation:
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Infraorbital hollows and tear trough deformities (sub-orbicularis oculi plane)
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Moderate lateral canthal lines (crow’s feet)
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Mid-Face Moderate Creases & Folds:
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Moderate nasolabial folds (smile lines running from the nose to mouth)
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Moderate marionette lines (oral commissure lines)
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Glabellar frown lines (as a companion to neuromodulators)
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Perioral & Lip Contouring:
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Vertical perioral lines (moderate smoker’s / lipstick lines)
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Subtle lip border definition (vermilion border contouring and philtral column enhancement)
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Mild oral commissure elevation
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Facial Scars & Etchings:
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Moderate atrophic facial scars and acne scar depression lifting
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Key Clinical Advantages
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Patented CPM® Seamless Integration: The variable-density matrix allows the gel to diffuse uniformly between host collagen fibers, creating natural transitions without edges or visible demarcations.
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The Clinical Standard for Tear Troughs: Because of its high cohesivity and uniform light transmission, it virtually eliminates the Tyndall effect (bluish skin discoloration), making it a global injector favorite for delicate under-eye treatments.
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Superficial to Mid-Dermal Versatility: Safe for mid-dermis deposition as well as superficial blanching techniques for stubborn, etched dynamic lines.
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Low Extrusion Resistance: Glides smoothly through 27G and 30G needles or microcannulas, ensuring controlled micro-aliquot delivery and minimal procedural tissue trauma.
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Available with Lidocaine: Offered with 0.3% lidocaine hydrochloride (Belotero Balance (+)) to ensure procedural comfort and high patient compliance.
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Predictable Longevity: Delivers sustained clinical results lasting 6 to 12 months, depending on injection technique, depth, and patient metabolic rate.
Technical Specifications
| Parameter | Specification |
| Active Substance | Cross-linked Sodium Hyaluronate (available with or without Lidocaine HCl) |
| HA Concentration | 22.5 mg/mL |
| Lidocaine Concentration | 0.3% (3 mg/mL) in Belotero Balance (+) |
| Cross-Linking Technology | CPM® (Cohesive Polydensified Matrix / Dynamic Cross-Linking) |
| Packaging Presentation | 1 x 1.0 mL pre-filled sterile glass syringe |
| Included Needles | 1 x 27G 1/2” (13 mm) and 1 x 30G 1/2” (13 mm) ultra-thin wall needles |
| Target Injection Plane | Mid-to-deep dermis, superficial reticular dermis, or pre-periosteal tear trough |
| Recommended Injection Tools | 27G / 30G needle or 25G / 27G blunt-tip microcannula |
| Expected Clinical Duration | 6 to 12 months (up to 9–12 months in the tear trough area) |
| Storage Instructions | Store between 2°C to 25°C (36°F to 77°F); protect from light and freezing |
| Manufacturer | Merz Aesthetics / Merz Pharmaceuticals (Manufactured in Switzerland/Europe) |
| Regulatory Category | US FDA Approved / CE-marked Class III Medical Device / Rx Only |
Professional Advisory: Belotero® Balance is a medical-grade injectable device strictly intended for licensed physicians, dermatologists, plastic surgeons, and credentialed aesthetic practitioners trained in advanced periorbital and mid-dermal injection anatomy. Not authorized for non-clinical or direct consumer use.






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