GTM EXOSCALP® Exosome Scalp Booster | CMED / GTM Cosmetics (South Korea)

Short Description

An advanced, dual-phase regenerative scalp and hair restoration booster system pairing freeze-dried EXO SIGNAL 1000 Exosome Powder (100 mg) with Scalp Renew Solution (5 mL). Formulated with multipotent cell-derived exosomes, Copper Tripeptide-1, Biotin, Panthenol, Niacinamide, Caffeine, and PDRN, GTM EXOSCALP® targets follicular miniaturization, androgenetic alopecia, and scalp senescence—reactivating dermal papilla signaling, prolonging the anagen growth phase, and restoring hair density and tensile strength.

Detailed Description

GTM EXOSCALP® is a professional-grade regenerative trichology injectable and micro-channeling solution developed in South Korea by CMED Co., Ltd. / GTM Cosmetics. Specifically calibrated to address non-scarring hair loss and compromised scalp microenvironments, it bypasses standard topical limitations by utilizing nanoscale extracellular vesicles (exosomes) that interact directly with the follicle’s biological niche.

The system functions through a two-phase reconstitution protocol:

1. Vial 1: EXO SIGNAL 1000 Lyophilized Powder (100 mg): Contains freeze-dried extracellular vesicles isolated from multipotent cell culture conditioned media. These nano-vesicles (~30–150 nm) carry native microRNAs, mRNA, and bioactive signaling proteins directly into dermal papilla cells (DPCs). This cellular signaling activates the Wnt/$\beta$-catenin pathway, downregulates localized inflammatory cytokine cascades (such as TGF-$\beta$ and IL-6), and stimulates dormant telogen follicles to transition back into the active anagen (growth) phase.

2. Vial 2: Scalp Renew Solution (5 mL Activator): A concentrated liquid nutrient vehicle designed to reconstitute the exosome powder while delivering targeted follicle stimulants and barrier-restoring compounds:

   • Copper Tripeptide-1 (GHK-Cu) & Biomimetic Peptides: Inhibit localized 5-$\alpha$-reductase activity, stimulate microvascular angiogenesis around the follicle bulb, and enlarge miniaturized hair shafts.

   • Salmon PDRN (Polydeoxyribonucleotide): Supplies essential purine and pyrimidine nucleotides via the salvage pathway, accelerating DNA repair and cellular mitosis within the germinative hair matrix.

   • Biotin (Vitamin B7) & Panthenol (Pro-Vitamin B5): Fortify keratin protein cross-linking, improve hair shaft tensile strength, and deliver deep moisture to dry, irritated scalp tissue.

   • Niacinamide (Vitamin B3) & Caffeine: Stimulate microvascular blood flow to the follicular papilla, counteracting vasoconstriction and optimizing oxygen and micronutrient perfusion.

   • Zinc PCA & Hyaluronic Acid: Balance excessive sebum production, soothe micro-inflammation, and re-establish hydration in the scalp barrier.

Treatment Areas & Indications

• Androgenetic Alopecia (AGA):

  • Male-pattern hair loss (Norwood Stages II–V), targeting the receding frontotemporal hairline and crown thinning

  • Female-pattern hair loss (Ludwig Stages I–II), targeting diffuse widening of the central part

• Telogen Effluvium (Acute & Chronic):

  • Excessive reactive shedding triggered by hormonal shifts, nutritional stress, post-febrile illnesses, or systemic shock

• Diffuse Miniaturization & Fragile Hair:

  • Thinning hair caliber, loss of structural volume, and early breakage

  • Slow hair growth cycles and poor follicle anchorage

• Compromised Scalp Barrier Health:

  • Dry, flaky, or chronically inflamed scalp tissue lacking vascular nourishment

  • Excessive sebum production and clogged follicular infundibula

• Hair Restoration Surgery Optimization:

  • Pre-transplant scalp conditioning to enrich recipient bed vascularity

  • Post-hair transplant graft support to improve follicle survival rates and speed donor-area tissue healing

Key Clinical Advantages

• Intact Exosome Potency via Freeze-Drying: Lyophilization preserves the structural integrity of fragile vesicular membranes and intra-exosomal growth factors, ensuring biological activity upon chairside reconstitution.

• Reverses Follicular Miniaturization: Combines cellular genetic signaling with peptide-driven angiogenesis to widen follicular diameter and produce thicker terminal hair shafts.

• Dual Mechanistic Action (Signaling + Nutrient Fuel): Provides the biological instructions (exosomes) to reactivate dormant dermal papilla cells alongside the building blocks (PDRN, amino acids, vitamins) required for keratin synthesis.

• Non-Hormonal Safety Profile: Delivers 5-$\alpha$-reductase modulation and follicle reactivation without systemic anti-androgenic side effects, making it suitable for both male and female patients.

• Broad In-Clinic Applicability: Fluid, easily absorbable formula suitable for automated microneedling pens (MTS), fractional laser scalp therapy, or intradermal micro-papular mesotherapy protocols.

• Fast Reduction in Shedding: Clinically observable reduction in hair shedding typically occurs within 2 to 4 weeks, with progressive improvements in hair density and thickness emerging over 8 to 12 weeks.

Technical Specifications

Professional Advisory: GTM EXOMELA® / EXOSCALP® is a professional-use regenerative trichology solution strictly intended for certified dermatologists, trichologists, and aesthetic physicians trained in scalp microneedling and mesotherapy protocols. It is not formulated for intravenous injection.