Dysport® 500 Units | Galderma / Ipsen (AbobotulinumtoxinA)
Short Description
The high-yield 500 Speywood Units presentation of Dysport® (AbobotulinumtoxinA) is engineered for high-volume aesthetic clinics, multi-zone facial rejuvenation, and large-muscle body contouring. Developed by Ipsen and distributed by Galderma, this formulation delivers rapid clinical onset, a soft feathering diffusion gradient, and maximum cost efficiency for clinical practice workflows.
Detailed Description
Dysport® 500 Units is a high-potency injectable neuromodulator containing AbobotulinumtoxinA derived from Clostridium botulinum type A. The 500 Speywood Units vial is designed to support comprehensive clinical sessions requiring higher unit allocations—such as combined full-face dynamic line correction, masseter thinning, platysmal band relaxation, and focal hyperhidrosis—without opening multiple smaller vials.
Dysport features an active neurotoxin complex distributed around 300 to 500 kDa. This molecular configuration provides a broader, uniform field of diffusion compared to classic 900 kDa complexes, facilitating seamless blending across wide muscle sheets (like the frontalis and platysma) while preventing harsh, over-frozen transition borders.
Treatment Areas & Indications
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Comprehensive Upper Facial Dynamics:
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Severe glabellar frown lines (Corrugator and Procerus complex)
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Extensive forehead dynamic rhytids (Frontalis feathering)
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Lateral periorbital lines (Crow’s feet)
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High-Unit Myomodulation & Body Contouring:
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Bilateral masseter muscle hypertrophy (Jawline V-shaping and severe bruxism)
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Trapezius muscle relaxation and shoulder slimming (“Barbie Tox” / neck lengthening)
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Platysmal banding and lower facial lifting (Nefertiti Lift)
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Depressor Anguli Oris (DAO) and mentalis puckering
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Dermatological & Therapeutic Protocols:
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Severe primary axillary hyperhidrosis (typically requiring 100–200 Speywood units per axilla)
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Palmar and plantar hyperhidrosis
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Key Clinical Advantages
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Clinic Workflow & Cost Efficiency: The 500U single-vial format minimizes packaging waste, lowers cost-per-unit for the practice, and simplifies high-volume treatment days.
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Rapid Clinical Action: Neuromuscular relaxation typically manifests within 24 to 48 hours, making it the fastest-acting neuromodulator available.
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Uniform Spread & Soft Feathering: Exceptional lateral blending makes it ideal for broad, flat muscle groups where rigid immobilization is undesirable.
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Robust Global Validation: Backed by US FDA, European EMA, and international clearances across both aesthetic and medical indications, with over 30 years of safety data.
Technical Specifications
| Parameter | Specification |
| Active Substance | AbobotulinumtoxinA (Clostridium botulinum Type A Toxin-Haemagglutinin Complex) |
| Nominal Strength | 500 Speywood Units per vial |
| Potency Ratio | Speywood Units are specific to Dysport assays (commonly applied at an approximate clinical ratio of 2.5:1 to 3:1 relative to standard 100U onabotulinumtoxinA) |
| Formulation | Lyophilized sterile white powder in a vacuum-sealed glass vial |
| Excipients | 125 mcg Human Albumin, 2.5 mg Lactose monohydrate |
| Manufacturer / Distributor | Ipsen Biopharm Ltd. |
| (UK) / Galderma | |
| Reconstitution Agent | Sterile, preservative-free 0.9% Sodium Chloride Injection (e.g., 2.5 mL yields 20U / 0.1 mL; 1.25 mL yields 40U / 0.1 mL) |
| Storage Specifications | Refrigerate unopened at 2°C to 8°C. Do not freeze. Protect from light. |
| Administer within 24 hours of reconstitution | Regulatory Category | Prescription Medicine (Rx) — Strictly for Licensed Medical Practitioners |
Professional Advisory: Dysport® 500 Units contains proprietary Speywood Units and cannot be exchanged 1:1 with any other botulinum toxin product. This product is strictly restricted to licensed dermatologists, plastic surgeons, and qualified clinical practitioners.









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