Demure® Grand (1 x 10 mL) | South Korea

Short Description

A high-viscoelasticity, macro-volumizing Hyaluronic Acid dermal and body filler formulated with 24 mg/mL of cross-linked HA in an economical 10 mL high-capacity syringe. Engineered for deep subcutaneous and supraperiosteal placement, Demure® Grand delivers high lifting capacity ($G’$), stable structural projection, and long-lasting tissue support for deep facial contouring (cheeks, chin, jawline), severe fold correction, and targeted non-surgical body contouring lasting 12 to 18+ months.

Detailed Description

Demure® Grand 10 mL is an advanced, sterile, non-pyrogenic physiological cross-linked sodium hyaluronate injectable manufactured in South Korea. Formulated as the high-density structural flagship of the Demure filler series, it provides aesthetic physicians with the volume capacity and mechanical strength required to treat extensive age-related volume deflation, correct skeletal contour deficiencies, and perform targeted macro-volumetric tissue augmentation.

Synthesized using non-animal bio-fermented hyaluronic acid, Demure Grand utilizes advanced multi-phase cross-linking technology to create a dense, monophasic 3D polymer lattice. This molecular configuration produces an elevated elastic modulus ($G’$) and strong internal cohesion, allowing the hydrogel to withstand mechanical compression and dynamic muscle shear (such as the masseter, mentalis, and gluteal complexes) without flattening, spreading laterally, or migrating into neighboring tissue planes.

Subjected to exhaustive dialysis purification, residual BDDE cross-linkers and bacterial endotoxins are reduced to non-detectable trace levels, promoting tissue biocompatibility and minimizing post-treatment swelling, erythema, and downtime. Supplied as a pure, lidocaine-free formulation, Demure Grand grants clinicians complete flexibility to tailor patient-specific pain management protocols (such as regional nerve blocks or custom lidocaine/saline blending) according to procedural requirements.

Treatment Areas & Indications

• Midface Structural Volumization & Malar Sculpting:

  • Malar and cheekbone augmentation (Zygomatic arch projection)

  • Correction of severe midface volume collapse and deep submalar hollows

  • Redensification and structural support for deflated deep fat pads

• Lower Face Contouring & Profile Harmonization:

  • Chin augmentation, forward projection, and vertical lengthening (retrognathia and microgenia correction)

  • Mandibular angle definition and sharp linear jawline border sculpting

  • Pre-jowl sulcus effacement and structural labiomental groove elevation

• Deep Facial Folds & Depressions:

  • Severe nasolabial folds requiring deep structural foundation support

  • Deep marionette lines and oral commissure structural descent

  • Deep temporal fossa restoration (temple lifting)

• Non-Surgical Body Contouring & Deficit Correction:

  • Lateral pelvic depression filling (hip dip correction)

  • Non-surgical gluteal volume enhancement and shaping

  • Dorsal hand rejuvenation and subcutaneous soft-tissue replenishment

  • Correction of post-traumatic indentations or post-liposuction contour irregularities

Key Clinical Advantages

• High-Capacity 10 mL Format: Specifically calibrated for large-volume structural procedures, eliminating the need to open multiple small syringes while optimizing procedural time and clinic economics.

• High-Density 24 mg/mL Formulation: Delivers high lifting power ($G’$) and projection capacity, creating sharp bone-mimetic architecture that holds its vertical height under soft-tissue tension.

• Cohesive Resistance to Migration: High internal polymer cohesion anchors deep subcutaneous and supraperiosteal deposits securely at the targeted anatomical plane, preventing lateral displacement.

• Exhaustive Dialysis Purification: Rigorous washing cycles eliminate residual cross-linkers and bacterial proteins, significantly minimizing post-procedure tissue swelling, redness, and recovery downtime.

• Pure Lidocaine-Free Hydrogel: Allows practitioners complete clinical freedom to customize local anesthesia, tumescent solutions, or lidocaine admixtures based on anatomical zone and patient tolerance.

• Smooth Cannula & Needle Extrusion: Glides evenly through 18G–21G body cannulas or 22G–25G facial cannulas, providing continuous extrusion force and precise retrograde fanning.

• Extended Clinical Longevity: Densely cross-linked HA chains resist endogenous hyaluronidase degradation, sustaining structural volume for 12 to 18+ months (and up to 24 months in stable structural zones).

Technical Specifications

Professional Advisory: Demure® Grand 10 mL is a high-density, large-volume medical injectable intended strictly for certified dermatologists, plastic surgeons, and credentialed aesthetic physicians trained in deep facial anatomy, supraperiosteal bolus delivery, and large-bore cannula body contouring. Injection into the breast parenchyma, glabella, periorbital zone, or superficial papillary dermis is strictly contraindicated.