Belotero® Soft (1 x 1.0 mL) | Merz Aesthetics
Short Description
An ultra-cohesive, low-viscosity Hyaluronic Acid dermal filler engineered with Merz’s patented CPM® (Cohesive Polydensified Matrix) technology. Formulated specifically for superficial intradermal placement, Belotero® Soft is the clinical gold standard for the superficial Blanching technique—effectively erasing delicate fine lines, perioral smoker’s lines, crow’s feet, and horizontal neck rings with zero risk of the Tyndall effect.
Detailed Description
Belotero® Soft is an advanced, sterile, biodegradable cross-linked hyaluronic acid gel designed to correct superficial cutaneous micro-depressions and delicate dynamic etching. Powered by proprietary CPM® Dynamic Cross-Linking technology, the gel features a monophasic matrix with variable-density zones that integrate into the upper papillary and reticular dermis.
Because of its exceptionally high cohesivity and low viscosity, Belotero Soft distributes smoothly within the superficial dermal architecture without pooling into distinct boluses or displacing surrounding tissue. This fluid elasticity allows injectors to treat fine lines at depth planes that would cause visible nodules or blueish light refraction (the Tyndall effect) with conventional biphasic or higher-density fillers.
Treatment Areas & Indications
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Superficial Perioral & Periorbital Rhytids:
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Fine perioral vertical lines (smoker’s lines / barcode lines)
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Lateral canthal fine lines (superficial crow’s feet)
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Subtle under-eye and lower eyelid fine crepiness
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Delicate Facial Etchings:
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Superficial horizontal forehead creases and shallow interbrow lines
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Fine smile lines / superficial accordion lines around the midface and cheeks
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Neck & Décolletage Rejuvenation:
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Horizontal neck lines and creases (“Tech Neck” / necklace lines)
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Décolleté fine crepiness and sleep lines
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Key Clinical Advantages
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The Benchmark for the Blanching Technique: Engineered to be safely injected into the high superficial dermis using serial micro-punctures or superficial blanching, immediately effacing fine lines without post-treatment visibility.
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Zero Tyndall Effect: Its cohesive, polydensified structure mimics endogenous skin tissue density, eliminating light-scattering blue discoloration even in paper-thin periocular and perioral areas.
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Patented CPM® Integration: Delivers seamless tissue conformity that moves in complete synergy with dynamic facial expressions, eliminating lumps, ridges, or foreign-body sensation.
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Smooth, Low-Force Extrusion: Glides effortlessly through ultra-fine 30G needles, providing pinpoint volumetric micro-control and minimizing tissue trauma, bruising, and patient downtime.
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Available with Lidocaine: Formulated with 0.3% lidocaine hydrochloride (Belotero Soft (+)) to provide localized anesthetic comfort during sensitive superficial dermal passes.
Technical Specifications
| Parameter | Specification |
| Active Substance | Cross-linked Sodium Hyaluronate (available with or without Lidocaine HCl) |
| HA Concentration | 20 mg/mL |
| Lidocaine Concentration | 0.3% (3 mg/mL) in Belotero Soft (+) presentations |
| Cross-Linking Technology | CPM® (Cohesive Polydensified Matrix) |
| Packaging Presentation | 1 x 1.0 mL pre-filled sterile glass syringe |
| Included Needles | 2 x 30G 1/2” (13 mm) ultra-thin wall disposable needles |
| Target Injection Plane | Superficial dermis (intradermal / upper reticular dermis) |
| Recommended Injection Technique | Blanching technique, superficial micro-puncture, or serial linear threading |
| Expected Clinical Duration | 6 to 12 months (dependent on treated area, skin quality, and patient metabolism) |
| Storage Conditions | Store at 2°C to 25°C (36°F to 77°F); protect from sunlight and freezing |
| Manufacturer | Merz Aesthetics / Merz Pharmaceuticals (Switzerland / Europe) |
| Regulatory Category | CE-marked Class III Medical Device / Rx Only |
Professional Advisory: Belotero® Soft is a medical-grade injectable device intended strictly for certified physicians, dermatologists, plastic surgeons, and credentialed aesthetic practitioners skilled in intradermal and superficial blanching injection methodologies. Not intended for direct consumer or home use.






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