Dermofill® Classic (1 x 10 mL) | Juvanix Laboratories Paris

Short Description

A versatile, mid-to-high density Hyaluronic Acid dermal and contouring filler formulated with 20–24 mg/mL of cross-linked HA in an economical 10 mL high-capacity presentation. Engineered for mid-to-deep dermal, subcutaneous, and supraperiosteal placement, Dermofill® Classic provides balanced viscoelastic lift ($G’$), smooth tissue integration, and natural contour retention for multi-zone facial contouring (cheeks, chin, jawline), severe fold correction, and extensive soft-tissue volume replenishment lasting 10 to 14+ months.

Detailed Description

Dermofill® Classic 10 mL is an advanced, sterile, non-pyrogenic physiological cross-linked sodium hyaluronate injectable developed by Juvanix Laboratories Paris (France). Positioned as the foundational, all-around workhorse of the Dermofill 10 mL portfolio, it bridges the gap between fluid tissue integration and structural mechanical support.

Synthesized from non-animal bio-fermented hyaluronic acid, Dermofill Classic utilizes advanced monophasic cross-linking technology to form an evenly distributed 3D polymer hydrogel network. This balanced rheological architecture provides moderate-to-high elastic modulus ($G’$) with fluid shear thinning, enabling the gel to extrude smoothly through cannulas and integrate cohesively between host tissue planes without creating palpable stiffness, nodules, or artificial contour demarcation.

Subjected to multi-stage dialysis purification, unreacted BDDE cross-linker residues and bacterial endotoxins are reduced to negligible trace levels. The resulting hydrogel promotes tissue biocompatibility, minimal post-treatment swelling, and predictable in vivo integration. Supplied as a pure, lidocaine-free formulation, Dermofill Classic allows aesthetic practitioners total flexibility to tailor patient-specific pain management protocols (such as regional nerve blocks or cannula-assisted lidocaine blending). Packaged in a generous 10 mL pre-filled syringe, it delivers high clinical utility and cost efficiency for comprehensive, full-face rejuvenation and localized body touch-ups in a single session.

Treatment Areas & Indications

• Midface Volumization & Softening:

  • Malar and cheekbone augmentation with natural projection

  • Correction of moderate-to-severe midface volume loss and submalar hollows

  • Accordion lines and lateral cheek soft-tissue filling

• Lower Face Contouring & Harmonization:

  • Moderate chin augmentation and profile elongation

  • Mandibular angle refinement and linear jawline border sculpting

  • Pre-jowl sulcus effacement and lower face vector support

• Severe Facial Folds & Depressions:

  • Moderate-to-severe nasolabial folds (lines from nasal ala to oral commissures)

  • Marionette lines and downward oral commissure elevation

  • Labiomental groove (mental crease) softening

• Large-Scale Facial & Localized Soft-Tissue Replenishment:

  • Temporal hollow correction (temple lifting)

  • Filling of atrophic facial scars and post-traumatic soft-tissue deficits

  • Dorsal hand rejuvenation and subcutaneous volume replenishment

Key Clinical Advantages

• High-Capacity 10 mL Format: Eliminates the necessity of opening multiple 1.0 mL syringes during multi-area facial sessions, streamlining procedural workflow while optimizing clinic economics.

• Balanced Rheological Profile: Harmonizes cohesive elasticity ($G’$) with dynamic fluidity, delivering predictable lifting power while adapting naturally to active facial expressions without a stiff, artificial appearance.

• Monophasic Cohesive Integration: Distributes evenly across deep dermal and subcutaneous planes, minimizing risks of product migration, lumpiness, or visible surface ridges.

• Exhaustive Dialysis Purity: Multi-stage washing reduces unreacted cross-linkers and endotoxins to non-detectable trace levels, substantially reducing post-injection erythema, edema, and clinical downtime.

• Pure Lidocaine-Free Formulation: Grants practitioners complete clinical freedom to customize anesthesia (local infiltration, nerve block, or customized cannula blending) according to individual patient tolerance and anatomical depth.

• Smooth Micro-Extrusion: Glides evenly through 21G–25G cannulas or 25G/27G needles, ensuring steady extrusion forces and accurate retrograde fanning.

• Dependable In Vivo Longevity: Densely cross-linked HA matrix resists endogenous hyaluronidase degradation, maintaining aesthetic correction for 10 to 14+ months.

Technical Specifications

Professional Advisory: Dermofill® Classic 10 mL is a prescription-grade medical injectable intended strictly for certified dermatologists, plastic surgeons, and credentialed aesthetic physicians skilled in deep facial anatomy, microcannula techniques, and vascular safety protocols. Injection into the breast parenchyma, glabella, periorbital zone, or superficial papillary dermis is strictly contraindicated.