Juvéderm® Ultra 4 (2 x 1.0 mL) | Allergan Aesthetics

Short Description

The most robust, high-viscosity formulation in the classic Hylacross™ collection, Juvéderm® Ultra 4 with 0.3% lidocaine is engineered for treating deep cutaneous depressions, correcting severe facial folds, and providing structural midface volume enhancement. Designed for deep dermal and subcutaneous placement, it delivers pronounced projection, cohesive tissue support, and smooth contours lasting up to 12 months.

Detailed Description

Juvéderm® Ultra 4 is an advanced, sterile, pyrogen-free cross-linked hyaluronic acid gel of non-animal origin, developed by Allergan Aesthetics (an AbbVie company). Utilizing Allergan’s proprietary Hylacross™ technology, Ultra 4 features a completely monophasic, non-particulate gel matrix with a higher degree of cross-linking and viscosity compared to Ultra 2 and Ultra 3.

This dense, cohesive molecular architecture provides high lifting capacity ($G’$) and strong resistance to in vivo shear stress and mechanical compression. Ultra 4 effectively fills deep tissue valleys, restores deflated structural compartments, and smooths severe dynamic folds while preserving natural facial mobility without post-injection displacement or beadiness.

Treatment Areas & Indications

• Severe Facial Folds & Depressions:

  • Severe nasolabial folds (deep creases extending from the oral commissures to the nose)

  • Deep marionette lines and profound oral commissure descent

  • Severe labiomental groove (crease between the lower lip and chin)

• Facial Volumization & Structural Contouring:

  • Mild-to-moderate malar and cheek volume restoration

  • Chin augmentation, projection, and mental crease effacement

  • Mandibular border and jawline contouring

• Tissue Deficit Restoration:

  • Deep subcutaneous tissue loss and age-related facial volume depletion

Key Clinical Advantages

• Maximum Hylacross™ Lifting Power: Features the highest cross-linking density in the Ultra line, offering substantial structural support and projection for severe soft-tissue deficits.

• Cohesive Monophasic Flow: Unlike biphasic granular gels that can scatter or feel uneven under palpation, Ultra 4 integrates smoothly into deep anatomical planes for a continuous, uniform contour.

• Integrated 0.3% Lidocaine: Formulated with lidocaine hydrochloride to minimize procedural discomfort during deep extrusion, enhancing the clinical injection experience.

• Low Extrusion Resistance: Despite its high viscosity, the cohesive matrix extrudes evenly through 27G needles, granting the practitioner pinpoint volumetric control.

• Proven In Vivo Stability: Highly resistant to endogenous hyaluronidase and oxidative breakdown, sustaining corrective results for up to 12 months.

Technical Specifications

Protect from freezing and direct lightManufacturerAllergan Aesthetics / AbbVie (Manufactured in Pringy, France)Regulatory CategoryCE-marked Class III Medical Device / Prescription Only (Rx)

Professional Advisory: Juvéderm® Ultra 4 is a medical-grade injectable device strictly restricted to certified dermatologists, plastic surgeons, and qualified aesthetic practitioners trained in advanced deep dermal and subcutaneous volumizing techniques. Not intended for superficial dermal application or non-clinical administration.