Belotero® Volume (2 x 1.0 mL) | Merz Aesthetics
Short Description
A high-density, deeply cohesive Hyaluronic Acid dermal filler engineered with Merz’s patented CPM® (Cohesive Polydensified Matrix) technology. Featuring the highest HA concentration in the Belotero portfolio (26 mg/mL), Belotero® Volume is designed for deep structural volumization, midface projection, temporal hollow restoration, and chin sculpting—delivering lifting capacity ($G’$) with natural dynamic tissue integration lasting up to 18 months.
Detailed Description
Belotero® Volume is a sterile, biodegradable cross-linked hyaluronic acid injectable formulated to restore pronounced facial volume deficits. Utilizing proprietary CPM® technology (Dynamic Cross-Linking), the gel features variable-density zones within a monophasic matrix—combining high-density cross-linked domains for structural projection with low-density domains for seamless tissue integration.
Unlike traditional heavy volumizers that can feel rigid or cause distinct margins under the skin, Belotero Volume balances elasticity, plasticity, and cohesivity. It molds smoothly into surrounding fat compartments and supraperiosteal planes, respecting natural facial dynamics and moving naturally with facial expressions without displacement or localized firmness.
Treatment Areas & Indications
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Midface Volumization & Malar Sculpting:
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Severe midface volume deficit and age-related hollows
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Malar and cheekbone projection (Zygomatic arch enhancement)
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Submalar hollow correction
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Upper & Lower Face Structural Contouring:
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Temporal hollow restoration (temple filling)
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Chin augmentation, projection, and elongation (microgenia / retrogenia correction)
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Jawline definition and pre-jowl sulcus effacement
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Deep Tissue Atrophy:
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Age-related deep fat compartment deflation and bone resorption support
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Key Clinical Advantages
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Patented CPM® Dynamic Cross-Linking: Creates variable micro-densities that allow the gel to integrate into subcutaneous architecture, eliminating the Tyndall effect and visible demarcation lines.
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Optimal Malleability & Projection: Combines high lifting power ($G’$) with modeling plasticity, allowing practitioners to mold and sculpt harmonious contours immediately after placement.
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Smooth Injection Mechanics: Extrudes evenly through 27G needles and cannulas, reducing hand fatigue and minimizing tissue shearing during deep bolus or retrograde deposition.
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Available with Lidocaine: Formulated with 0.3% lidocaine hydrochloride (Belotero Volume (+)) to optimize patient comfort throughout deep-plane administration.
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Sustained In Vivo Durability: Highly resistant to mechanical breakdown and enzymatic degradation, delivering volume retention for up to 18 months.
Technical Specifications
| Parameter | Specification |
| Active Substance | Cross-linked Sodium Hyaluronate (available with or without Lidocaine HCl) |
| HA Concentration | 26 mg/mL (Highest in the Belotero® portfolio) |
| Lidocaine Concentration | 0.3% (3 mg/mL) in Belotero Volume (+) presentations |
| Cross-Linking Technology | CPM® (Cohesive Polydensified Matrix / Dynamic Cross-Linking) |
| Packaging Presentation | 2 x 1.0 mL pre-filled sterile glass syringes (Total 2.0 mL) |
| Supplied Needles & Cannulas | 2 x 27G 1/2” needles, 2 x 30G 1/2” needles, and 2 x 27G cannulas with puncture needles |
| Target Injection Plane | Deep subcutaneous layer or supraperiosteal (pre-periosteal) plane |
| Recommended Tools | 27G needle or 25G / 27G blunt-tip microcannula |
| Expected Longevity | Up to 18 months (dependent on anatomical site, dosage, and tissue metabolism) |
| Storage Instructions | Store between 2°C to 25°C (36°F to 77°F); protect from light and freezing |
| Manufacturer | Merz Aesthetics / Merz Pharmaceuticals (Manufactured in Switzerland/Europe) |
| Regulatory Category | CE-marked Class III Medical Device / US FDA Approved / Rx Only |
Professional Advisory: Belotero® Volume is a medical injectable strictly indicated for licensed physicians, plastic surgeons, dermatologists, and certified aesthetic injectors trained in deep facial anatomy and vascular safety. Not intended for superficial intradermal injection or consumer use.






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